Endocrine Abstracts

Background: The prevalence of polycystic ovary syndrome (PCOS) in adolescents is reported up to 38.9%. Obesity is a known risk factor associated with PCOS increasing the risk of metabolic syndrome (MS). Up to 25% of adolescents with PCOS may have derangements in glucose metabolism and insulin resistance (IR).Aim: To evaluate PCOS prevalence in overweight/obese adolescent girls and to assess the association with BMI, MS and IR.Metho...

Introduction: Management of patientswith congenital adrenal hyperplasia (CAH) is a challenge to find a right balance of glucocorticoid doses and long-term consequences of overtreatment isassociated with increased risk of cardiometabolic disorders.The aim of our study was to evaluate body mass index (BMI), body composition, blood pressure (BP) and insulin sensitivity in children and youth with CAH in comparison with healthy control subjects.<p class="...

Introduction: Hypothyroidism is associated with a spectrum of symptoms affecting almost all bodily functions. We present a case of severe hypothyroidism with multiple body cavity effusions, volvulus of sigma creating ileus.Case report: A 70 year old female was admitted to emergency department with dyspnea, and acute abdominal pain. Physical examination was notable for anasarca, abdominal fluid wave, lower extremity pitting edema, hypotension. She did not...

Introduction: Two major strategies can be used to verify the diagnosis of ascending aortic dilatation in Turner syndrome (TS): the diameter of the aorta adjusted for body surface area (BSA) can be estimated or the ratio of the ascending/descending aorta may be assessed.Aim: To identify the difference of the prevalence of ascending aortic dilatation in patients with Turner syndrome by measuring the diameter of the ascending aorta adjusted for BSA and by e...

Introduction: Turner syndrome (TS) is associated with specific physical features, as well as a particular neuropsychological profile and social and behavioral features. It is common practice in the case of TS to treat short stature with growth hormone preparations and to induce puberty with estrogens at an age as close to normal puberty as possible. Nevertheless results of some studies show that despite the treatment, some women with TS still experience psychosocial problems, ...

Introduction: Stereotactic radiotherapy and more relevant pharmacotherapy are widely used for PA’s treatment; however transsphenoidal surgery remains gold standard. Postoperative complications and endocrinological outcomes vary widely and are related with surgeon experience and tumor characteristics.The aim of this study: To determine relationship between pituitary adenoma size and transsphenoidal pituitary adenoma surgery outcomes.<p class="abs...

Background: Data on the effects of long term glucocorticoid (GC) treatment on bone mineral density (BMD) in patients with congenital adrenal hyperplasia (CAH) are controversial. Objectives: To evaluate BMD and vitamin D status in adolescents and young adults with CAH in comparison with healthy controls.Methods: 32 patients with classical CAH (13 males; mean of age 26.0±7.1 years (14.0–37.3) were compared to 32 healthy con...

Background: Diabetic retinopathy (DR) is one of the most common complications resulting from uncontrolled diabetes mellitus (DM). DR is the leading cause of blindness and low vision. DR is usually diagnosed at an advanced stage, so despite the individual treatment, it is only possible to slow down the progression of DR. Therefore, new potential biomarkers are needed for an earlier DR prognosis to prevent the development of DR. According to the latest studies, ubiquitin-proteas...

Introduction: ACTH producing macroadenoma and pituitary apoplexy are rare in Cushing’s disease. Somatostatin receptor agonist Pasireotide is indicated for the treatment of patients with Cushing’s disease for whom surgery is not an option or has failed. We present a case of pituitary apoplexy in patient with recurrence of Cushing’s disease treated with Pasireotide.Case: 38 years old female presented with quick weight gain, weakness, irregul...

Introduction: Low levels of vitamin D are commonly found in people with type 1 diabetes and recently studies found that vitamin D deficiency (VDD) contributes to the risk of developing diabetic microvascular complications. The aim was to determine the relationship between microvascular complications of diabetes and 25-hydroxyvitamin D (25(OH)D) levels in type 1 diabetic patients.Methods: A total of 143 adults (60 male and 83 female) with type 1 diabetes ...